A snow squall watch is posted for north and east Lambton.
Environment Canada said squalls with local snowfall amounts possibly exceeding 15 centimetres are possible Thursday night and Friday.
The national weather agency said intense snow squall activity is expected to affect areas east of Lake Huron, but may also affect portions of Middlesex and Lambton counties.
Gusty winds up to 60 kilometres an hour could also result in poor visibility in areas of blowing snow.
Motorists are advised to adjust their driving to the changing road and weather conditions.